Recent Peer reviewed journal papers

  1. T. Mullen, M. Callaghan, S. McClean.  Invasion of Burkholderia cepacia complex isolates into lung epithelial cells involves glycolipid receptors.  Microb Path. 49:381-387 (2010)
  2. Wright, C., Herbert, G, Pilkington, R, Callaghan, M, McClean, S.  Real-time PCR method for the quantification of Burkholderia cepacia complex attached to lung epithelial cells and inhibition of that attachment. Lett Applied Micro. 50 (2010): 500-506
  3. McKeon, S, McClean, S., Callaghan, M. Burkholderia cepacia complex (Bcc) interactions with alveolar macrophages in vitro.  FEMS Immunology and Medical Microbiology, (2010)  Oct;6036-43. PMID: 20602636.
  4. Seshu Kaza Kumar, Siobhán McClean, Máire Callaghan. IL-8 released from human lung epithelial cells induced by cystic fibrosis pathogens Burkholderia cepacia complex affects growth and intracellular survival of bacteria. International Journal of Medical Microbiology. PMID: 20829108 
  5. Creaven BS, Czeglédi E, Devereux M, Enyedy EA, Foltyn-Arfa Kia A, Karcz D, Kellett A, McClean S, Nagy NV, Noble A, Rockenbauer A, Szabó-Plánka T, Walsh M.   Biological activity and coordination modes of copper(ii) complexes of Schiff base-derived coumarin ligand.  Dalton Trans 2010 PMID 20949224.  
  6. Sam Maher, Marc Devocelle, Sinéad Ryan, Siobhán McClean, David J Brayden.   Impact of amino acid replacements on in vitro  permeation enhancement and cytotoxicity of the intestinal absorption promoter, melittin.  International Journal of pharmaceutics, 387 (2010) 154–160. 
  7. Creaven, BS, Devereux, M, Foltyn, A, McClean, S, Rsair, G, Reddy Thangella, V,  Walsh, M.  Quinolin-2(1H)-one-triazole derived Schiff bases and their Cu(II) and Zn(II) complexes: Possible new therapeutic agents. Polyhedron (2010) 29 (2), 813-822 
  8. Maher, S., Vilk, G., Kelleher, F., Lajoie, G., McClean, S.  Chemical Modification of the Carboxyl Terminal of Nisin A with Biotin does not Abolish Antimicrobial Activity against the indicator organism,  Kocuria rhizophila.  Int J Pept Res & Therap.15:3  219-226 2009 
  9. Sam Maher, Xuexuan Wang, Victoria Bzik, Siobhan McClean and David J. Brayden  Evaluation of intestinal absorption and mucosal toxicity using two promoters. II. Rat Instillation and perfusion studies.   European Journal of Pharmaceutical Sciences
    volume 38, ( 4), 2009, pp. 291 - 300 
  10. McClean, S and Callaghan, M.  Burkholderia cepacia complex:  Epithelial cell-pathogen confrontations and potential for therapeutic intervention.   J. Med Micro.  58(Pt 1):1-12. (2009)  PMID 19074648   
  11. Maher, S., Feighery, L., Brayden DJ, McClean S.  Cracking the junction: Update on the progress of gastrointestinal absorption enhancement in the delivery of poorly absorbed drug.  Critical reviews in Therapeutic Drug Carrier Systems.  (2008) 25 (2) 117-168.  PMID: 18540837
  12. Maher, S. McClean, S.  Melittin exhibits necrotic cytotoxicity in gastrointestinal cells which is attenuated by cholesterol   (2008) Biochemical Pharmacology 75(5):1104-14.  PMID: 18068148
  13. Caraher E, Collins J, Herbert G, Murphy PG, Gallagher CG, Crowe MJ, Callaghan M, McClean S.  Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial cells.  J Med. Microbiol (2008)  57(Pt 1):15-20  PMID: 18065662
  14. Mullen T, Markey K, Murphy P, McClean S, Callaghan M. Role of lipase in Burkholderia cepacia complex (Bcc) invasion of lung epithelial cells.  Eur J Clin Microbiol Infect Dis. 2007  26(12):869-77 PMID: 17874328
  15. Caraher, EM, Gumulapurapu, K,  Taggart, CC, McClean, S, Callaghan, M.  The effect of recombinant human lactoferrin on growth and the antibiotic susceptibility of the CF pathogen Burkholderia cepacia complex when cultured planktonically or as biofilms.  J Antimicrobial Chemotherapy.  2007  60(3):546-54.  PMID: 17595284 [Cit = 2]
  16. Maher, S., Feighery, L., Brayden DJ, McClean S.  Melittin as an epithelial permeability enhancer I: Investigation of its mechanism of action in Caco-2 monolayers. (2007)  Pharm Res, PMID: 17380268 [Cit = 1]
  17. Maher, S., Feighery, L., Brayden DJ, McClean S.  Melittin as a permeability enhancer II: in vitro investigations in human mucus secreting intestinal monolayers and rat colonic mucosae.  (2007), Pharm Res,  PMID: 17373574  [Cit = 3]
  18. Caraher E, Reynolds G, Murphy P, McClean S, Callaghan M.  Comparison of antibiotic susceptibility of Burkholderia cepacia complex organisms when grown planktonically or as biofilm in vitro. Eur J Clin Microbiol Infect Dis. 2007; 26(3):213-6. PMID: 17265071 [Cit = 4]
  19. Duff C, Murphy PG, Callaghan M, McClean S.  Differences in invasion and translocation of Burkholderia cepacia complex species in polarised lung epithelial cells in vitro. Microb Pathog. 2006 Oct-Nov;41(4-5):183-92. PMID: 16938423 [Cit = 4]
  20. Caraher E, Duff C, Mullen T, Mc Keon S, Murphy P, Callaghan M, McClean S.  Invasion and biofilm formation of Burkholderia dolosa is comparable with Burkholderia cenocepacia and Burkholderia multivorans. J Cyst Fibros. 2007 Jan;6(1):49-56 PMID: 16781896 [Cit = 6]
  21. Maher S, McClean S.  Investigation of the cytotoxicity of eukaryotic and prokaryotic antimicrobial peptides in intestinal epithelial cells in vitro. Biochem Pharmacol. 2006 Apr 28;71(9):1289-98. PMID: 16530733 [Cit = 6]
  22. Brayden DJ, Templeton L, McClean S, Barbour R, Huang J, Nguyen M, Ahern D, Motter R, Johnson-Wood K, Vasquez N, Schenk D, Seubert P.   Encapsulation in biodegradable microparticles enhances serum antibody response to parenterally-delivered beta-amyloid in mice. Vaccine. 2001 Jul 20;19(30):4185-93. PMID: 11457544 [Cit = 12]
  23. Conway MA, Madrigal-Estebas L, McClean S, Brayden DJ, Mills KH.  Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: effect of formulation and route of immunization on induction of Th1 and Th2 cells. Vaccine. 2001 Feb 28;19(15-16):1940-50.  PMID: 11228364 [Cit = 31]