Neurochemical Analysis using Microdialysis with Integrated Microsensor
This Cycle 4 PRTLI funded project is in collaboration with Prof. John Lowry’s team at NUI Maynooth and will examine a sampling device combined with a microfluidic flow cell with incorporated sensor suitable for in vivo analysis of neurochemical activity. This will include the investigation of alternative probe designs, materials and optimisation of analyte recovery from the sample.The Integration of sensor technology with the sampling device will be critical together with the evaluation and testing of new electrocatalysts to enable selective voltammetric detection of e.g. glutamate, hydrogen peroxide, dopamine and lactate. The device will be tested in vivo and in vitro with the aid of expertise and access to facilities at NUI Maynooth to demonstrate on-line monitoring and to investigate in vivo the relationships between brain hydrogen peroxide and dopamine.
